Services & technologies

Services and technologies

End-to-end API value chain management, leveraging science, technology and know how to deliver rapid, right quality value add solutions
Our goal is to understand the environment in which we operate and combine this with listening to our customers to deliver their targets in delivering high quality, value add, safe and effective medicines. An example of this broadening of capabilities is Sterling's SCIENCE BEFORE SALES - SB(4)S program - offering greater insight into products and their performance to allow faster economic decision making by clients, Sterling offers an end-to-end partnership for the research, development and manufacture of APIs. The flexibility of our customized solutions allows us to create long lasting value relationship and build success with our customers.
Our goal is to understand the environment in which we operate and combine this with listening to our customers to deliver their targets in delivering high quality, value add, safe and effective medicines. An example of this broadening of capabilities is Sterling's SCIENCE BEFORE SALES - SB(4)S program - offering greater insight into products and their performance to allow faster economic decision making by clients, Sterling offers an end-to-end partnership for the research, development and manufacture of APIs. The flexibility of our customized solutions allows us to create long lasting value relationship and build success with our customers.
SONO-CRYSTALLIZATION

Sono-Crystallization is a technology involving the application of ultrasound energy to control the nucleation and crystal growth of a crystallization process.

Crystallization consists of two major events:

  1. NUCLEATION
  2. CRYSTAL GROWTH

And the application of ultrasound energy impacts both events

  1. In nucleation, molecules gather together in clusters in a define manner. These clusters need to be stable to reach the “critical cluster size” or they will redissolve. Ultrasound radiation is known to induce acoustic cavitation in liquids through the formation, growth, and collapse of bubbles. The collapse of the bubble provides energy to encourage the nucleation process at the earliest possible point in time.
  1. During the crystal growth, nuclei that have successfully achieved the “critical cluster size” begin to increase in size. Ultrasound radiation is controlled during the crystal growth phase to determine the growth rate, size, and shape of the crystal structures.

Sono-Crystallization is a technology involving the application of ultrasound energy to control the nucleation and crystal growth of a crystallization process.

Crystallization consists of two major events:

  1. NUCLEATION
  2. CRYSTAL GROWTH

And the application of ultrasound energy impacts both events

  1. In nucleation, molecules gather together in clusters in a define manner. These clusters need to be stable to reach the “critical cluster size” or they will redissolve. Ultrasound radiation is known to induce acoustic cavitation in liquids through the formation, growth, and collapse of bubbles. The collapse of the bubble provides energy to encourage the nucleation process at the earliest possible point in time.
  1. During the crystal growth, nuclei that have successfully achieved the “critical cluster size” begin to increase in size. Ultrasound radiation is controlled during the crystal growth phase to determine the growth rate, size, and shape of the crystal structures.

STERLING TECHNOLOGY

GMP-PLANT LOCATED IN PERUGIA (ITALY) SITE

  • Ultrasonic amplification system 9SNC-01
  • Dedicated vessels for solvent and anti-solvent systems
  • Automated process
  • De-agglomeration (twin screws feeder) system available, if needed
  • Processable qty: from approx. 500 g up to tens Kgs (depending on solubility)

Analytical equipment for PSD control: Malvern Mastersizer 2000 with “wet” unit

STERLING TECHNOLOGY

GMP-PLANT LOCATED IN PERUGIA (ITALY) SITE

  • Ultrasonic amplification system 9SNC-01
  • Dedicated vessels for solvent and anti-solvent systems
  • Automated process
  • De-agglomeration (twin screws feeder) system available, if needed
  • Processable qty: from approx. 500 g up to tens Kgs (depending on solubility)

Analytical equipment for PSD control: Malvern Mastersizer 2000 with “wet” unit

MANUFACTURING PROCESS

  1. Raw Materials
  2. Dissolution
  3. Crystallization
  4. Filtration
  5. Drying
  6. De-agglomeration
  7. Analysis
  8. Storage
  9. Release

MANUFACTURING PROCESS

  1. Raw Materials
  2. Dissolution
  3. Crystallization
  4. Filtration
  5. Drying
  6. De-agglomeration
  7. Analysis
  8. Storage
  9. Release